English Vocab

Staying Ahead of The Double Helix
India needs a law against genetic discrimination. There are enough models available globally.
The Delhi High Court recently ruled against discrimination in health insurance by United India Insurance Company involving a person with a heart condition which was perceived to be a genetic disorder. The court held, “Discrimination in health insurance against individuals based on their genetic disposition or genetic heritage, in the absence of appropriate genetic testing and laying down of intelligible differentia, is unconstitutional.”

While the specific features of this case may depend on clauses in the original policy, this is a critical court decision around the broader question of discrimination on the basis of one’s genetic predisposition. As technology for genetic testing and tools to gather family history and compile them in databases become cheaper and more widespread, it becomes imperative that due social and ethical consideration be given to genetic discrimination as the implications are far-reaching and can affect everyone.
Questionable assumptions
Genetic discrimination (GD) is understood to be differential treatment of those not showing symptoms but who are nevertheless treated differently on the basis of any real or assumed genetic characteristics. We must recognise that GD is nothing new. There were robust policies of eugenics (the science of improving a population by controlled breeding to increase the occurrence of desirable heritable characteristics) in the U.S. in the 1900s. These led to laws in many States that made sterilisation compulsory for those who expressed a range of conditions believed to be inherited. Such conditions covered those with disability, who were poor, had mental health problems, were promiscuous (consisting of a wide range of different things), were dwarfs, and so on. Eugenics was also practiced in many countries in Europe, not just in Nazi Germany. Nordic countries, for example, passed eugenics laws in the 1930s and some of those stayed in the books until the 1970s.
With newer and cheaper methods to sequence entire genomes, the era of expanded genetic testing is already upon us, although not everyone may associate it with eugenics. Whether specific genetic tests themselves are scientifically valid, whether they add value to those tested, and whether they should be generalised for populations or communities raise a separate but linked set of issues that I will not cover in this article. Rather, I will stay focussed on the issues of insurance and employment when there is family history of disease, the potential complications of genetic tests and their implications.
American precedent
In the U.S., researchers working with the Council for Responsible Genetics in Cambridge, Massachusetts recorded hundreds of cases of misuse of genetic information obtained through family history, genetic tests, or by employers and insurers accessing personal data.
There are many examples of employers and insurers using genetic information to engage in discriminatory policies. In 2001, the Burlington Northern Santa Fe Railroad Company settled a federal lawsuit in the U.S. The company had violated the Americans with Disabilities Act by threatening to fire a worker who did not give a blood sample to test whether he was predisposed to developing carpal tunnel syndrome. The company conducted genetic tests on its employees without their consent as a means of thwarting (to prevent (someone) from doing something or to stop (something) from happening) compensation claims for job-related stress injuries. A person diagnosed with a condition that causes excessive iron storage, but whose symptoms are otherwise manageable, lost her health insurance despite clear medical evidence that she was healthy.
In the U.S., the Genetic Information Nondiscrimination Act (GINA) was signed into law in 2008. GINA provides strong protection against access to genetic information and genetic discrimination in the context of health insurance and employment. It prohibits insurers from “requesting or requiring” genetic tests from an individual or members of the person’s family, or using genetic information to determine eligibility or establish premiums. It also prohibits employers from “requesting or requiring” genetic information for hiring or promotional decisions, or when determining eligibility for training programmes.
Geneticists are not in agreement on the usefulness of genetic tests or even on their veracity (the quality of being truthful or honest). Most importantly, very few single-gene health problems exist and the vast array of common diseases is related to the functioning of networks of genes in the milieu (the physical or social setting in which something happens or develops) of other central cellular components and also depend on lifestyle and environment.
Too much miscommunication
Moreover, the popular notion of deoxyribonucleic acid (otherwise known as DNA) being the central and only player in cellular and genetic information and disease with a mere unfolding of characteristics is deeplyflawed (blemished, damaged, or imperfect in some way). While there is mounting evidence to oppose this perception of DNA as a master molecule, there is a lot of miscommunication among scientists and the media on this topic wherein a gene that codes for a protein associated with the outward expression of a condition is regarded as its cause. Correcting this perception, even when genetic reductionist paradigms have shifted, is an uphill battle when commercial interests such as testing have been unleashed.
The Council of Europe has adopted a set of recommendations on the use of genetic information for the purpose of insurance. Canada’s recent Genetic Non-Discrimination Act makes it illegal for insurers or employers to request DNA testing or results. It is reported that insurers in the U.K. are currently under a voluntary moratorium (a time when a particular activity is not allowed) agreed upon between the Association of British Insurers and the government until 2019. Based on this agreement, results from genetic tests are not to be used for health or life insurance except for Huntington’s disease, which is dominantly inherited with a high penetrance. This simply means that there is a high likelihood that those who have this gene develop the disease, which is inherited as an autosomal-dominant trait. But it must be noted here that even with the rare single-gene conditions the genetic expression varies significantly because of other factors.
India too needs a law that prevents genetic discrimination. In this era of rampant (unrestrained in action or performance) genetic testing, we need to prevent discrimination and uphold “equal treatment under the law”. Would the court have ruled the same way if the insurance company had done a genetic test and included a clause that this particular heart condition would not be covered? Equality under the law cannot have exceptions.
A complex future
The situation is likely to get worse as people become more accepting of predictive genetic tests and insurance companies insist on them; at the moment, they generally use family medical history as the basis for determining premiums. In the medium term, there are also serious concerns related to the protection and privacy of medical and genetic data. Breaking into databanks, as we are all familiar by now, is not impossible as even America’s Federal Bureau of Investigations and other secure firewalls have beenbreached (An act of breaking or failing to observe a law, agreement, or code of conduct).
Looking beyond these immediate issues, everyone has genes for some predisposition or the other, this being the human condition. There should therefore be no discrimination based on genetic information. Insurance is developed from pooling risks. If companies begin to insist on tests for everyone, then potentially no one will be insurable. Only universal health care can therefore be a viable (having the possibility of being achieved or developed) solution.
Courtesy-The Hindu (General Studies)
1. Eugenics (noun) : (The science of improving a population by controlled breeding to increase the occurrence of desirable heritable characteristics.) (सुजनन विज्ञान, संतति विज्ञान)
Synonyms: Genetic, Hereditary
Antonyms: Dysgenic
Example: Even though I don’t believe in eugenics, I wish some people had thought seriously before becoming parents
Related words: Eugenic, Eugenist (adjective) Eugenically (adverb) Eugenicist, (noun)
2. Promiscuous (adjective) : (Consisting of a wide range of different things.) (अनेक प्रकार का)
Synonyms: Assorted, Eclectic, Heterogeneous, Miscellaneous, Mixed, Motley,
Antonyms: Homogeneous, Monolithic, Uniform; Alike, Identical,
Example: Since I just collect stamps that I happen to like, my collection is pretty promiscuous.
Related words: Promiscuously (adverb) Promiscuousness (noun)
3. Thwart (verb) : (To prevent (someone) from doing something or to stop (something) from happening.) (नकाम बनाना, रोकना)
SynonymsBaffle, Balk, Discomfit, Foil, Impede, Hamper
Antonyms: Cultivate, Encourage, Foster, Assist, Promote
Example: In order to thwart the advancing enemy troops, the captain ordered the explosives team to destroy the bridge.
Verb forms: Thwart, Thwarted, Thwarted
Related words: Thwarter (noun) Thwartly (adverb)
4. Veracity (noun) : (The quality of being truthful or honest) (यथार्थता, सच्चाई)
Synonyms: Honesty, Integrity, Probity, Truthfulness, Verity, Authenticity
Antonyms: Deceit, Dishonesty, Lying, Mendacity, Hypocrisy, Falsehood
Example: Unless you get your information from a credible website, you should doubt the veracity of the facts until you have confirmed them elsewhere.
Related words: Veracious (adjective)
5. Milieu (noun) : (The physical or social setting in which something happens or develops) (परिवेश, हालत, स्थिति)
Synonyms: Environment, Habitat, Sphere, Ambiance, Circumstances, Entourage
Antonyms: Generality, Suffusion, Diapason
Example: Because my father grew up in a military milieu, he knew he wanted to join the armed forces when he graduated from high school.
6. Flawed (adjective) : (Blemished, damaged, or imperfect in some way.) (त्रुटिपूर्ण)
Synonyms: Imperfect, Faulty, Erroneous, Fallacious, Inaccurate, Blemished
Antonyms: Perfect, Impeccable, Immaculate
Example: There was a flaw in the dancer’s routine, but no one seemed to notice her mistake.
Verb forms: Flaw, Flawed, Flawed
Related words: Flaw (verb) Flawedness, (noun) Unflawed, (adjective)
 
7. Moratorium (noun) : (A time when a particular activity is not allowed) (रोक, अधिस्थगन, प्रतिबंध)
Synonyms: Embargo, Ban, Prohibition, Postponement, Halt, Adjournment, Deferment    
Antonyms: Continuance, Expedite, Accelerate, Recommencement
Example: Potential business owners are angry because the county has passed a moratorium on new business licenses.
Related words: Moratory (adjective)
 
8. Rampant (adjective) : (Unrestrained in action or performance.) (अनियंत्रित, उग्र, प्रबल)
Synonyms: Uncontrolled, Violent, Impatient, Intemperate, Frenzied
Antonyms: Restrained, Calm, Placid, Abstemious, Balmy, Clement
Example: Under the administration of the crooked sheriff, corruption was rampant on the police force.
Related words: Rampantly (adverb)
9. Breach (noun) : (An act of breaking or failing to observe a law, agreement, or code of conduct.) (उल्लंघन)
Synonyms: Contravention, Violation, Infringement, Transgression, Dereliction
Antonyms: Agreement, Obedience, Connection, Abidance
Example: After the officer’s breach of conduct was discovered, he was dishonorably discharged from the military.
Verb forms: Breach, Breached, Breached
Related words: Breach (verb) Breacher (noun) Unbreached, (adjective)
10. Viable (adjective) : (Having the possibility of being achieved or developed) (व्यवहार्य, होने योग्य)
Synonyms: Workable, Feasible, Practical, Applicable, Manageable, Operable, Tenable
Antonyms: Impossible, Impracticable, Infeasible, Unachievable, Dormant
Example: Once upon a time, solar power was not viewed as a viable energy source.
Related words: Viability (noun) Viably (adverb) Unviable (adjective)

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